Expression patterns and prognostic value of RUNX genes in kidney cancer

Abstract Kidney cancer is the third most common malignancy of urinary system, which, kidney renal clear cell carcinoma (KIRC) accounts for vast majority. Runt-related transcription factors (RUNX) are involved in multiple cellular functions. However, diverse expression patterns and prognostic values RUNX genes remained to be elucidated. In our study, we mined DNA methylation, transcriptional survival data patients with different kinds through Oncomine, Gene Expression Profiling Interactive Analysis, UALCAN, Kaplan–Meier Plotter, cBioPortal LinkedOmics. We found that RUNX1 RUNX3 were upregulated KIRC tissues compared those normal tissues. The analysis results indicated a high level was associated poor overall (OS) patients. Furthermore, tumor had significantly lower levels promoter methylation than paracancerous tissues, decreased notably OS KIRC. conclusion, revealed may potential therapeutic target treating KIRC, shows promise as novel diagnostic biomarker, which laid foundation further study.